Precision Medicine relies on advent medical imaging technique, fusion of multi-modality medical imaging and information, and large-scale data mining on medical cases. Our research group focuses on challenging problems in surgical navigation in congenital heart disease, such as identifying hearts’ anatomical structure, real-time decision support in surgery and early assessment of surgical effect. We aim to establish an intelligent auxiliary platform for complex congenital heart disease, adopting advanced 2D to 3D image registration algorithms and intelligent vasculopath planning algorithms, our research team has hemodynamic theories and machine learning methods, as well as the facilitation of treatment plan and intraoperative navigation. At present, we have developed a multi-functional 3D image processing and display system. Our research work is supported by joint fund key projects from Natural Science Foundation of China (NSFC).